Search CommunityWalk:


Adlyfe Inc.

9430 Key West Avenue
Rockville, MD 20850, USA

Category: Diagnostic/Imaging; Research Services & Supplies

Used in the following map:

Maryland Biotech Industry Map

Adlyfe Inc. is a biotechnology company, focused on bringing innovative diagnostic products to the market for neurodegenerative diseases. It was founded in 2003 to develop novel technologies for blood testing for early targets of amyloid diseases. The company is developing a novel test for the detection and amplification of amyloid proteins as early biomarkers of fatal brain diseases.

Adlyfe's novel technology is based on the synthesis of small peptide, or Pronucleon(TM) ligands, that are amino acid sequence matched to target amyloids of interest. Ligand sequences are selected based on regions of the target protein known to undergo conformational changes (structural changes in shape) associated with amyloid formation.

Adlyfe is developing novel tests for the detection of human neurodegenerative diseases including: 1) Sporadic & variant Creutzfeldt - Jakob disease (sCJD, vCJD) for screening for the presence of misfolded prion proteins (PrPsc); 2) Animal TSE Diseases test - to detect prion misfolded protein (PrPsc) in of animals confirmed by matching brain tissue and Western Blot analysis with matching plasma samples; and 3) Alzheimer's Disease test for a-beta amyloid protein.

Adlyfe has signed an agreement with Wyeth Pharmaceuticals for the development of a biomarker assays designed to measure levels of beta amyloid in the human brain.