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Ascend Therapeutics, Inc.

607 Herndon Parkway, Suite 110
Herndon, VA 20170, USA

Category: Drug Delivery

Used in the following map:

Maryland Biotech Industry Map

Ascend Therapeutics, Inc. is a biopharmaceutical company that focuses on the research, development and use of transdermal drug delivery technology to overcome therapeutic barriers, thereby raising the standard of care for previously unmet chronic health conditions. It was founded in 2002 with a mission to develop and commercialize pharmaceuticals that have either greater efficacy, an improved safety profile or increased patient compliance, by leveraging its proprietary Enhanced Hydroalcoholic Gel technology.

Ascend uses its proprietary percutaneous hydroalcoholic gel technology, EHG(TM), to deliver therapy in instances where oral delivery is impossible or undesirable. Its EHG(TM) delivery mechanism allows the company to develop new, more effective therapies for unmet chronic health conditions, such as breast pain, gynecomastia and late-onset hypogonadism.

Ascend's technology allows for transdermal absorption of drugs through this barrier, using a proprietary combination of alcohol, water and a user-friendly permeation enhancer to temporarily loosen the intra-cellular bonds of the stratum corneum. This creates a channel through which the drug can enter the skin. Once the gel dries, the cell bonds tighten again, reforming the barrier membrane and trapping the drug in the skin. Its EHG(TM) Technology creates an 'invisible patch,' by enhancing the penetration of the active ingredient into the skin and allowing the skin itself to become the reservoir of drug release.

Ascend's product afimoxifene gel, an antiestrogen being evaluated for the treatment of cyclic breast pain and other estrogen dependent disorders in premenopausal women. The company's products include: Migranal for the treatment of the acute attack of migraine headaches; Suprax for the treatment of bacterial infections; Andrin for the treatment of late onset hypogonadism; Estrogel for the treatment of menopausal symptoms; Prochieve for the treatment of secondary amenorrhea and TamoGel for the treatment of cyclic breast pain.

Ascend's partners include: Lupin Ltd, Valeant Pharmaceuticals International, Columbia Laboratories Inc, Cornerstone Therapeutics, Inc. (formerly Cornerstone BioPharma, Inc.), PDI Inc and Besins International.