US 250 east end, 1928-1934 (probable)
near Grafton
US 220 south end, 1930-1934
New Creek
US 48[II] west end, 1973-1991
Morgantown
US 119 south end, 1926-1934
Morgantown
US 48[III] west end, 2002-present
Weston (Virginia signs their short segment of US 48, but the route is not expected to be signed in WV for several years.)
US 21 north end, 1971-1974
near Pocatalico
US 35 south end, 1934-1950s(?)
Charleston
US 35 south end, 1950s(?)-1970
Charleston
US 35 south end, 1970-2008
St. Albans (US 35 has been rerouted to a new endpoint northwest of here)
US 121 north end, 2005-present
Beckley (this road is under construction and is not expected to be signed as US 121 for several years. However, as of 2008 a short segment west of Beckley was signed as WV 121.)
US 219 south end, 1937-1980s (probable)
Princeton
US 52 east end, 1932-1934 (probable)
Bluefield
US 52 east end, 1926-1932
Huntington
US 35 south end, 2008-present
Scott Depot (just north of this marker is the location of the new interchange 40, which officially opened to traffic in Oct. 2008. US 35 extends south of that interchange, ending here at Teays Valley Rd. Switch to "Satellite" view to see the road under construction).